Open AccessThe Properties And Reactions Of Decamethonium Iodide And Hexamethonium Bromide
Author(s) -
Balaban I. E.,
Levy M. B.,
Wilde B. E.
Publication year - 1949
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.1949.tb12470.x
Subject(s) - iodide , hexamethonium , bromide , chemistry , decamethonium , medicinal chemistry , methyl iodide , organic chemistry , biochemistry , receptor
The work of Paton and Zaimis 1 on decamethonium iodide (α:ω‐hexamethyldiaminodecane diiodide, known as C.10) showed that it was a very potent substance, and that it was capable of replacing d ‐tubocurarine chloride in medicine. An antidote exists for decamethonium iodide in hexamethonium bromide (α:ω‐hexamethyldiaminohexane dibromide, known as C.6), and owing to its pharmacological properties this substance has been suggested for use in hypertension and vascular diseases, thereby replacing tetraethylammonium iodide. Hexamethonium bromide is 10 to 20 times as active as the tetraethyl compound. In view, therefore, of the possible importance of the new drugs, it was considered desirable that an examination should be made of their physical and chemical properties. We are indebted to Mr. F. Ridgway for carrying out some of the determinations.