Open AccessLong‐term brain and behavioral consequences of early iron deficiency
Author(s) -
Georgieff Michael K
Publication year - 2011
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.2011.00432.x
Subject(s) - iron deficiency , dopamine , brain function , hippocampal formation , neuroscience , term (time) , brain structure and function , physiology , psychology , endocrinology , biology , medicine , neuroimaging , anemia , physics , quantum mechanics
Early iron deficiency not only affects brain and behavioral function during the period of iron deficiency, it persists long after treatment. The mechanisms include long‐term alterations in dopamine metabolism, myelination, and hippocampal structure and function. Recent studies have demonstrated long‐term genomic changes, which suggests the regulation of brain function is fundamentally altered.