Open AccessImpact of conjugated linoleic acid on bone physiology: proposed mechanism involving inhibition of adipogenesis
Author(s) -
Ing Steven W,
Belury Martha A
Publication year - 2011
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.2011.00376.x
Subject(s) - adipogenesis , conjugated linoleic acid , adipose tissue , endocrinology , bone mass , osteoblast , medicine , chemistry , mechanism (biology) , mesenchymal stem cell , peroxisome proliferator activated receptor , mechanism of action , receptor , fat mass , linoleic acid , biology , microbiology and biotechnology , biochemistry , obesity , fatty acid , osteoporosis , in vitro , philosophy , epistemology
Conjugated linoleic acid (CLA) supplementation decreases adipose mass and increases bone mass in mice. Recent clinical studies demonstrate a beneficial effect of CLA on reducing weight and adipose mass in humans. This article reviews possible biological mechanisms of action of CLA on bone metabolism, focusing on modulation of nuclear receptor peroxisome proliferator‐activated receptor gamma activity to steer mesenchymal stem cell differentiation toward an adipose and away from an osteoblast lineage. Clinical studies of the effects of CLA on bone mass and clinical implications of the effects of CLA on bone health in humans are summarized and discussed.