Open AccessNuclear receptors of the enteric tract: guarding the frontier
Author(s) -
Schmidt Daniel R,
Mangelsdorf David J
Publication year - 2008
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.2008.00092.x
Subject(s) - nuclear receptor , receptor , biology , pregnane x receptor , calcitriol receptor , homeostasis , microbiology and biotechnology , xenobiotic , biochemistry , gene , transcription factor , enzyme
In addition to its classical role in mineral homeostasis, the vitamin D receptor has been implicated in diverse physiologic and pathophysiologic processes including immunoregulation and cancer. Interestingly, the vitamin D receptor has been evolutionarily and functionally linked to a select group of nuclear receptors based on a common organism‐wide tissue expression profile. These members of the nuclear receptor superfamily, which include the bile acid receptor, xenobiotic receptors, and several orphan nuclear receptors, comprise a transcriptional regulatory network that functions in nutrient uptake, xenobiotic metabolism, and mucosal protection. The major homeostatic functions of the enteric nuclear receptor network are the topic of this review.