Open AccessFailure of Vitamin E in Clinical Trials: Is Gamma‐Tocopherol the Answer?
Author(s) -
Devaraj Sridevi,
Jialal Ishwarlal
Publication year - 2005
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.2005.tb00143.x
Subject(s) - tocopherol , oxidative stress , inflammation , medicine , clinical trial , vitamin e , disease , alpha tocopherol , vitamin d and neurology , vitamin , antioxidant , chemistry , biochemistry
Oxidative stress and inflammation play a crucial role in atherosclerosis. However, prospective clinical trials of dietary antioxidants with anti‐inflammatory properties, such as α‐tocopherol (AT), have not yielded positive results. AT supplementation decreases γ‐tocopherol (GT) levels. GT is an antioxi‐dant with potent anti‐inflammatory activity, and plasma GT levels are inversely associated with cardiovascular diseases. Thus, studies using pure GT, alone or in conjunction with AT, will elucidate its utility in cardiovascular disease prevention .