Open AccessImportance of Diet in Maternal Phenylketonuria
Author(s) -
Sheard Nancy F.
Publication year - 2000
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.2000.tb01871.x
Subject(s) - microcephaly , phenylalanine , pregnancy , medicine , phenylketonurias , endocrinology , pediatrics , biology , biochemistry , genetics , amino acid
Diet has long been recognized as the primary treatment modality for individuals with phenylketonuria (PKU) during infancy and childhood. Recent findings from the Maternal PKU Collaborative Study clearly indicate that dietary restriction of phenylalanine is also necessary to prevent the adverse effects of an elevated plasma phenylalanine concentration during pregnancy, which include microcephaly, physical anomalies, and mental retardation.