Open AccessThe Oxidation of 9‐cis‐Retinol: A Possible Synthesis Pathway for 9‐cis‐Retinoic Acid
Author(s) -
Wolf George
Publication year - 2000
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.2000.tb01833.x
Subject(s) - retinoic acid , retinol , retinaldehyde , alcohol dehydrogenase , kidney , enzyme , retinal , biochemistry , tretinoin , endocrinology , chemistry , medicine , biology , gene , vitamin
A short‐chain alcohol dehydrogenase has been discovered that oxidizes 9‐cis‐ and 11‐cis‐retinol to their corresponding aldehydes. The gene for this enzyme was sequenced and appears to be expressed with highest efficiency in the retinal pigment epithelium of the eye, as well as in human liver and mammary gland and in mouse liver and kidney. Because 9‐cis‐retinol occurs in liver, it may be a precursor of 9‐cis‐retinoic acid.