Open AccessIron Transport Across Biologic Membranes
Author(s) -
Andrews Nancy C.,
Fleming Mark D.,
Gunshin Hiromi
Publication year - 1999
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1999.tb06934.x
Subject(s) - yeast , membrane transport , transmembrane protein , transporter , membrane , chemistry , microbiology and biotechnology , biochemistry , biology , receptor , gene
Iron is essential for life, but is toxic in excess. Nearly all organisms have therefore developed regulated mechanisms for efficient transport of iron into cells. This paper reviews the current understanding of iron transport, focusing on valuable lessons from studies of yeast iron transport and the discovery of the first mammalian transmembrane iron transporter.