Open AccessDifferential Effects of Individual Trans Fatty Acid Isomers on Lipoprotein Assembly and Metabolism
Author(s) -
Matthan Nirupa R.,
Jones Peter J. H.
Publication year - 1999
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1999.tb01813.x
Subject(s) - metabolism , lipid metabolism , fatty acid , fatty acid metabolism , cis–trans isomerism , chemistry , biochemistry , lipoprotein , biology , stereochemistry , cholesterol
Recent findings indicate that certain (t‐C18:1Δ9) but not all (t‐C16:1 Δ9 and t‐C18:1 Δ11) trans fatty acid isomers influence intestinal lipoprotein secretion. A mechanism is suggested that appears to be sensitive to properties associated not only with geometric configuration but also with fatty acid chain length and double bond position. This mechanism could explain, in part, the conflicting results seen among studies investigating the effects of total dietary trans fatty acids on serum lipid and lipoprotein concentrations.