Open AccessCholesterol‐dependent Regulation of Nitric Oxide Production: Potential Role in Atherosclerosis
Author(s) -
Coppinger Ruth Jameson,
Baum Charles L.
Publication year - 1999
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1999.tb01812.x
Subject(s) - enos , nitric oxide , nitric oxide synthase , endothelium , cholesterol , nitric oxide synthase type iii , endothelial nitric oxide synthase , medicine , chemistry , endocrinology
Atherosclerosis is preceded by cholesterol‐induced diminution in vascular nitric oxide (NO) production and proatherogenic changes in endothelial cell function. Careful dissection of the steps involved in regulating endothelial nitric oxide synthase (eNOS) activity has revealed that cholesterol‐induced caveolin expression reduces NO production by stimulating the production of inhibitory caveolin eNOS complexes.