Open AccessIdentification of Nramp2 as an Iron Transport Protein: Another Piece of the Intestinal Iron Absorption Puzzle
Author(s) -
Fleet James C.
Publication year - 1998
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1998.tb01701.x
Subject(s) - iron binding proteins , hemochromatosis , hereditary hemochromatosis , enterocyte , hepcidin , identification (biology) , absorption (acoustics) , dmt1 , chemistry , biochemistry , biophysics , biology , transferrin , materials science , inflammation , transporter , immunology , genetics , small intestine , botany , gene , composite material
Although a number of iron‐binding proteins have been identified, the roles for specific proteins in mediating iron absorption have not been definitively assigned. Two recent papers report the identification of an iron transport protein that may be responsible for movement of iron from the intestinal lumen into the enterocyte. Coupled with the recent identification of the protein mutated in hemochromatosis, researchers are now establishing a clearer picture of the mechanism of intestinal iron absorption.