Open AccessInhibition of Cellular Uptake of Folate by Blocking Synthesis of the Membrane Folate Receptor
Author(s) -
Wolf George
Publication year - 1998
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1998.tb01700.x
Subject(s) - sphingolipid , folate receptor , fumonisin b1 , membrane , receptor , chemistry , biochemistry , mycotoxin , pharmacology , biology , cancer cell , food science , cancer , genetics
The folate receptor, bound to the plasma membrane through a glycosylphosphatidylinositol anchor, requires both sphingolipids and cholesterol in the membrane for full activity. In recent studies, treatment of cells in culture with the mycotoxin fumonisin 1′ , which inhibits sphingolipid synthesis, virtually abolished uptake of 5‐methyltetrahydrofolate.