Open AccessIron and Gene Expression: Molecular Mechanisms Regulating Cellular Iron Homeostasis
Author(s) -
Kühn Lukas C.
Publication year - 1998
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1998.tb01681.x
Subject(s) - cytoplasm , microbiology and biotechnology , gene expression , biology , transmembrane protein , regulation of gene expression , transcription (linguistics) , iron binding proteins , gene , transcription factor , homeostasis , translation (biology) , function (biology) , gene isoform , genetics , messenger rna , receptor , linguistics , philosophy
In recent years, specific post‐transcriptional mechanisms in the cytoplasm of vertebrate cells have been elucidated that directly affect the stability and translation of mRNAs coding for central proteins in iron metabolism. This review shall focus primarily on these mechanisms. Other levels of control, either affecting gene transcription and/or related to the function of iron‐capturing substances and transmembrane transport, are also likely to exist and to influence the iron balance and utilization. They are, however, much less clear.