Open AccessWill an Increased Dietary Folate Intake Reduce the Incidence of Cardiovascular Disease?
Author(s) -
Ubbink Johan B.,
Becker Piet J.,
Vermaak W. J. Hayward
Publication year - 1996
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1996.tb03936.x
Subject(s) - medicine , incidence (geometry) , coronary artery disease , disease , folic acid , food fortification , fortification , environmental health , cardiology , food science , biology , physics , optics
Based on a meta‐analysis of published studies, it has been estimated that approximately 10% of coronary artery disease cases are attributable to hyperhomocyst(e)inemia. It has also been calculated that food fortification with folate might reduce the number of cases of coronary artery disease in the United States by 50,000 per year. However, the use of statistical concepts to estimate the expected benefits of this intervention strategy may be misleading.