Open AccessEffects of Positive Iron Status at a Cellular Level
Author(s) -
McCord Joe M.
Publication year - 1996
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1996.tb03876.x
Subject(s) - ferritin , iron status , lipid peroxidation , chemistry , oxidative phosphorylation , oxidative damage , iron deficiency , oxidative stress , biochemistry , medicine , anemia
The human body is not equipped to eliminate excess iron. As a result, cells continously store excess absorbed iron in a complex with the protein ferritin. This poses no great threat under normal conditions. However, under certain disease conditions, oxidative processes cause iron to be mobilized and released as Fe(II). This iron is capable of initiating lipid peroxidation, which can lead to loss of membrane structure and function.