Open AccessA New Metabolite of Retinol: All‐ trans ‐4‐oxo‐retinol As a Receptor Activator and Differentiation Agent
Author(s) -
Ph.D. Sharon A. Ross,
Ph.D Luigi M. De Luca
Publication year - 1996
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.1996.tb03802.x
Subject(s) - retinoic acid , retinol , metabolite , retinoid , retinoic acid receptor , activator (genetics) , retinoid x receptor , receptor , nuclear receptor , biology , tretinoin , cellular differentiation , retinoid x receptor gamma , retinoic acid receptor alpha , retinoid x receptor beta , signal transduction , biochemistry , chemistry , microbiology and biotechnology , cancer research , gene , transcription factor , vitamin
All ‐trans‐ 4‐oxo‐retinol, a metabolite of retinol synthesized in mouse embryonal carcinoma F9 cells, is active in inducing differentiation of these cells. It also functions as a ligand of retinoic acid receptors and a transcriptional activator of reporter genes. These findings may dispel the notion that retinoic acids are the only transactivators of retinoid receptor‐dependent pathways. However, there are weaknesses that need to be addressed in order to confirm the relevance of this retinol‐mediated signaling pathway.