Open AccessAssociation of Low Plasma Adiponectin With Early Diastolic Dysfunction
Author(s) -
Negi Smita I.,
Jeong EuyMyoung,
Shukrullah Irfan,
Raicu Mihai,
Dudley, Jr Samuel C.
Publication year - 2012
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1751-7133.2011.00276.x
Subject(s) - adiponectin , medicine , ejection fraction , endocrinology , body mass index , diastole , obesity , blood pressure , heart failure , insulin resistance
Diastolic dysfunction (DD) with preserved left ventricular (LV) ejection fraction (EF) has been linked to obesity. Adiponectin is a cytokine related to obesity and obesity‐linked cardiovascular complications. The authors aimed to determine the independent association of DD with adiponectin. Fifty patients with impaired relaxation DD and a normal EF and age‐matched normal controls were recruited. Plasma levels of total and high molecular weight (HMW) adiponectin were measured. Mid and low molecular weight (MMW+LMW) fractions of adiponectin were calculated by subtracting HMW fraction from total adiponectin. The DD group had significantly lower total (median, 4.4 vs 12.7 μg/mL; P =.001), HMW fraction (median, 1.3 vs 3.4 μg/mL; P =.02), and MMW+LMW fraction of adiponectin (median, 3.8 vs 7.2 μg/mL; P =.01). Body mass index (BMI) negatively correlated with total ( r :−0.46, P =.003), HMW ( r :−0.32, P =.038), and MMW+LMW ( r :−0.40, P =.006) fractions of adiponectin. DD had an independent association with both BMI ( P <.05) and total adiponectin ( P <.001) in linear regression model using sex, BMI, blood pressure, and total adiponectin as covariates. DD was associated with BMI ( P =.02), HMW fraction ( P =.03), and MMW+LMW fraction ( P =.004) in similar linear regression analyses. Adiponectin deficiency may be one explanation for the adiposity‐related cardiac oxidation known to be involved in the pathogenesis of DD.