Open AccessSleep and Health‐Related Quality of Life in Heart Failure
Author(s) -
Mills Paul J.,
Dimsdale Joel E.,
Natarajan Loki,
Ziegler Michael G.,
Maisel Alan,
Greenberg Barry H.
Publication year - 2009
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1751-7133.2009.00106.x
Subject(s) - medicine , heart failure , ejection fraction , quality of life (healthcare) , cardiology , sleep disordered breathing , sleep (system call) , heart rate , physical therapy , blood pressure , obstructive sleep apnea , nursing , computer science , operating system
This study characterized sleep in heart failure (HF) and determined associations with quality of life. Forty stable HF patients and 34 healthy volunteers were studied in a clinical research unit. HF patients had more central apneas per hour (17.6 vs 5.4; P≤.01) and obstructive apneas per hour (21.7 vs 8.5; P≤.05), spent more time in stage 1 sleep (54 vs 35 min; P≤.05), and had more respiratory awakenings following apneic events (27.2 vs 4.2; P≤.01). More HF patients were depressed (55% vs 27.2%; P≤.01) and had worse fatigue (P≤.05). In multiple regression analysis, physical functioning quality of life was predicted by reduced left ventricular ejection fraction (P≤.05), shorter distance on a 6‐minute walk test (P≤.05), greater fatigue (P≤.01), and more apneas ( P≤.05) (model R 2 =.672; P≤.001). Emotional functioning quality of life was predicted by greater fatigue (P≤.01) (model adjusted R 2 =.732; P<.001). Findings provide evidence that in addition to functional status and ongoing fatigue, poorer quality of life in HF is independently related to the severity of sleep‐disordered breathing.