Open AccessCell‐specific Regulation of APOBEC3F by Interferons
Author(s) -
YING Songcheng,
ZHANG Xuzhao,
SARKIS Phuong Thi Nguyen,
XU Rongzhen,
YU Xiaofang
Publication year - 2007
Publication title -
acta biochimica et biophysica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.771
H-Index - 57
eISSN - 1745-7270
pISSN - 1672-9145
DOI - 10.1111/j.1745-7270.2007.00275.x
Subject(s) - biology , cytidine deaminase , interferon , alpha interferon , virology , microbiology and biotechnology , immunology , antibody
Human cytidine deaminase APOBEC3F (A3F) has broad anti‐viral activity against hepatitis B virus and retroviruses including human immunodeficiency virus type 1. However, its regulation in viral natural target cells such CD4 + T lymphocytes, macrophages, and primary liver cells has not been well studied. Here we showed that A3F was up‐regulated by interferon (IFN)‐α in primary hepatocytes and multiple liver cell lines as well as macrophages. Although the IFN‐α signaling pathway was active in T lymphoid cells and induction of other IFN stimulated genes such as PKR was detected, A3F and APOBEC3G (A3G) were not induced by IFN‐α in these cells. Thus, additional factors other than known IFN‐stimulated genes also regulated IFN‐α‐induced A3F expression distinctly. A3F and A3G expression levels in primary hepatocytes, especially after IFN‐α stimulation, were comparable to those in CD4 + T lymphocytes in some individuals. Significant variations of A3F and A3G expression in primary hepatocytes from various subjects were observed. Individual variations in A3F and/or A3G regulation and expression might influence the clinical outcomes of hepatitis B infection.