Open AccessEx vivo antioxidant effects of D‐004, a lipid extract from Roystonea regia fruits, on rat prostate tissue
Author(s) -
Pérez Yohani,
Molina Vivian,
Mas Rosa,
Menéndez Roberto,
González Rosa M.,
Oyarzábal Ambar,
Jiménez Sonia
Publication year - 2008
Publication title -
asian journal of andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 74
eISSN - 1745-7262
pISSN - 1008-682X
DOI - 10.1111/j.1745-7262.2008.00385.x
Subject(s) - malondialdehyde , prostate , antioxidant , hyperplasia , testosterone (patch) , ex vivo , endocrinology , medicine , prostate cancer , lipid peroxidation , chemistry , biochemistry , in vitro , cancer
Aim: To investigate whether oral treatment with D‐004, a lipid extract of the Cuban royal palm fruit, produces antioxidant effects in the prostate tissue of normal and testosterone (T)‐treated rats. Methods: In our first experiment, normal rats were distributed into five groups: one group treated with the vehicle and four groups treated with D‐004 (100, 200, 400 or 800 mg/kg). In our second experiment, rats were randomized into five groups: a negative control group and four T‐injected groups. The latter were comprised of a positive control group treated with the vehicle, and three groups treated with D‐004 (200, 400 or 800 mg/kg). Results: In normal rats, D‐004 (100–800 mg/kg) inhibited significantly and dose‐dependently iron‐initiated malondialdehyde (MDA) accumulation in prostate homogenates (35.7%–80.0%) vs. the controls. D‐004 (200–800 mg/kg) significantly reduced baseline MDA and carbonyl groups in prostate homogenates of normal rats to approximately 80% and 50%, respectively, and totally (100%) in T‐treated rats. Conclusion: Oral treatment with D‐004 reduced MDA and carbonyl groups dose‐dependently and markedly in normal and T‐injected rats. These findings show that D‐004 given at doses effective to prevent prostate hyperplasia also produces antioxidant effects in the prostate tissue.