Open Access17beta‐estradiol stimulates proliferation of spermatogonia in experimental cryptorchid mice
Author(s) -
Li EnZhong,
Li DeXue,
Zhang ShiQing,
Wang ChangYong,
Zhang XueMing,
Lu JingYan,
Duan CuiMi,
Yang XiangZhong,
Feng LiXin
Publication year - 2007
Publication title -
asian journal of andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 74
eISSN - 1745-7262
pISSN - 1008-682X
DOI - 10.1111/j.1745-7262.2007.00288.x
Subject(s) - luteinizing hormone , testosterone (patch) , medicine , spermatogenesis , endocrinology , estrogen , follicle stimulating hormone , sexual maturity , hormone , andrology , biology
Aim: To investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice. Methods: Mice were surgically rendered cryptorchid, then treated with different doses of 17β‐estradiol (E2) s.c. once a day. Mice were killed at sexual maturity (45 days of age), and histological analysis and immunofluorescence were performed. Serum follicle stimulating hormone (FSH), estradiol, testosterone and luteinizing hormone (LH) were measured. Results: Low doses of E2 had no notable effect on spermatogonia, but at higher doses, E2 stimulated the proliferation of spermatogonia. Conclusion: E2 has a dose‐related mitogenic effect on spermatogonia.