Open AccessGenetic and epigenetic risks of intracytoplasmic sperm injection method
Author(s) -
Georgiou Ioannis,
Syrrou Maria,
Pardalidis Nicolaos,
Karakitsios Konstantinos,
Mantzavinos Themis,
Giotitsas Nikolaos,
Loutradis Dimitrios,
Dimitriadis Fotis,
Saito Motoaki,
Miyagawa Ikuo,
Tzoumis Pavlos,
Sylakos Anastasios,
Kanakas Nikolaos,
Moustakareas Theodoros,
Baltogiannis Dimitrios,
Touloupides Stavros,
Giannakis Dimitrios,
Fatouros Michael,
Sofikitis Nikolaos
Publication year - 2006
Publication title -
asian journal of andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 74
eISSN - 1745-7262
pISSN - 1008-682X
DOI - 10.1111/j.1745-7262.2006.00231.x
Subject(s) - intracytoplasmic sperm injection , epigenetics , infertility , biology , assisted reproductive technology , male infertility , gamete , population , sperm , andrology , bioinformatics , gynecology , genetics , medicine , pregnancy , gene , environmental health
Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection (ICSI) procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent that consequences of the genetic abnormalities underlying male subfertility (or infertility) and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities. Edited by Wolf‐Bernhard Schill