Open AccessTestosterone decreases adiponectin levels in female to male transsexuals
Author(s) -
Berra Marta,
Armillotta Francesca,
D'Emidio Laura,
Costantino Antonietta,
Martorana Giuseppe,
Pelusi Giuseppe,
Meriggiola Maria Cristina
Publication year - 2006
Publication title -
asian journal of andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 74
eISSN - 1745-7262
pISSN - 1008-682X
DOI - 10.1111/j.1745-7262.2006.00204.x
Subject(s) - adiponectin , medicine , endocrinology , leptin , testosterone (patch) , luteinizing hormone , body mass index , waist , lean body mass , follicle stimulating hormone , sex hormone binding globulin , hormone , insulin , insulin resistance , androgen , obesity , body weight
Aim: To evaluate the effect of testosterone (T) on adiponectin serum levels in transsexual female patients. Methods: We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment (100 mg Testoviron Depot /10 days, i.m.). Results : Adiponectin levels were 16.9 ± 7.3 mg/mL at baseline and 13.5 ± 7.4 mg/mL at month 6 of T treatment ( P < 0.05). Leptin and high‐density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected. Conclusion: T can significantly reduce adiponectin serum levels in transsexual female patients.