Open AccessPeyronie's disease: a silent consequence of diabetes mellitus
Author(s) -
Tefekli A.,
Kandirali E.,
Erol B.,
Tunc M.,
Kadioglu A.
Publication year - 2006
Publication title -
asian journal of andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 74
eISSN - 1745-7262
pISSN - 1008-682X
DOI - 10.1111/j.1745-7262.2006.00099.x
Subject(s) - medicine , peyronie's disease , erectile dysfunction , diabetes mellitus , risk factor , outpatient clinic , penis , deformity , surgery , sexual dysfunction , endocrinology
Aim: To investigate the clinical characteristics of patients with Peyronie's disease (PD) and diabetes mellitus (DM). Methods: During an 8‐year period, a total of 307 men seen at our outpatient clinic were diagnosed with PD. Clinical characteristics, penile deformities and the erectile status of patients with PD and DM together ( n = 102) were retrospectively analyzed and compared to patients with PD alone with no risk factors for systemic vascular diseases ( n = 97). Results: The prevalence of PD among men with DM and sexual dysfunction was 10.7 %. The mean age of diabetic patients with PD was (55.9 ± 8.9) years; in the no risk factor group it was (48.5 ± 9.0) years ( P < 0.05). The median duration of DM was 5 years. The majority of diabetic patients with PD (56.0 %) presented in the chronic phase ( P < 0.05), and they were more likely to have a severe penile deformity ( P > 60°) than the no risk factor group ( P < 0.05). In the diabetic group, the most common presenting symptom was penile curvature (81.4 %), followed by a palpable nodule on the shaft of the penis (22.5 %) and penile pain with erection (14.7 %). A total of 19.6 % of patients were not aware of their penile deformities in the diabetic group. Erectile function, provided by history and in response to intracavernosal injection and a stimulation test, was significantly diminished in patients with PD and DM ( P < 0.05). Conclusion: DM probably exaggerates the fibrotic process in PD. Diabetic patients with PD have a higher risk of severe deformity and erectile dysfunction (ED). PD seems to be a silent consequence of DM and should be actively sought in diabetic men.