Open AccessAltered ATP‐sensitive potassium channels may underscore obesity‐triggered increase in blood pressure 1
Author(s) -
FAN Lihong,
TIAN Hongyan,
MA Aiqun,
HU Zhi,
HUO Jianhua,
CAO Yongxiao
Publication year - 2008
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2008.00810.x
Subject(s) - mesenteric arteries , blood pressure , endocrinology , medicine , potassium channel , obesity , blood vessel , vascular smooth muscle , potassium , chemistry , atp sensitive potassium channel , artery , smooth muscle , diabetes mellitus , glibenclamide , organic chemistry
Aim: To determine whether ATP‐sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity‐triggered increase in blood pressure. Methods: Obesity was induced by 24 weeks of high‐fat diet feeding in male Sprague‐Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, K ATP channel‐mediated relaxation responses in the aortas and mesenteric arteries, K ATP channel current, and gene expression were examined, respectively. Results: Blood pressure and body weight were increased in rats fed with high‐fat diet. K ATP channel‐mediated relaxation responses, currents, and K ATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion: Altered ATP‐sensitive potassium channels in obese rats may underscore obesity‐triggered increase in blood pressure.