Open AccessGlial involvement in trigeminal central sensitization 1
Author(s) -
XIE Yufeng
Publication year - 2008
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2008.00801.x
Subject(s) - sensitization , neuroscience , central nervous system , purinergic receptor , glutamatergic , central sensitization , medicine , trigeminal nerve , stimulus (psychology) , trigeminal ganglion , nociception , receptor , glutamate receptor , anesthesia , psychology , sensory system , psychotherapist
Recent studies have indicated that trigeminal neurons exhibit central sensitization, an increase in the excitability of neurons within the central nervous system to the extent that a normally innocuous stimulus begins to produce pain after inflammation or injury, and that glial activities play a vital role in this central sensitization. The involvement of glial cells in trigeminal central sensitization contains multiple mechanisms, including interaction with glutamatergic and purinergic receptors. A better understanding of the trigeminal central sensitization mediated by glial cells will help to find potential therapeutic targets and lead to developing new analgesics for orofacial‐specific pain with higher efficiency and fewer side‐effects.