Open AccessFunctional subtypes of renal α 1 ‐adrenoceptor in diabetic and non‐diabetic 2K1C Goldblatt renovascular hypertension
Author(s) -
ARMENIA A,
SATTAR Munavvar Abdul,
ABDULLAH Nor Azizan,
KHAN Md Abdul Hye,
JOHNS Edward James
Publication year - 2008
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2008.00788.x
Subject(s) - medicine , endocrinology , methoxamine , nitrendipine , phenylephrine , vasoconstriction , adrenergic , diabetes mellitus , renovascular hypertension , kidney , blood pressure , agonist , receptor
Aim: This study investigates the subtypes of the α 1 ‐adrenoceptor mediating the adrenergically‐induced renal vasoconstrictor responses in streptozotocin‐induced diabetic and non‐diabetic 2‐kidney one clip (2K1C) Goldblatt hypertensive rats. Methods: The renal blood flow responses to renal nerve stimulation, noradrenaline, phenylephrine, and methoxamine were measured in the absence and presence of nitrendipine, 5‐methylurapidil, chloroethylclonidine and BMY 7378. Results: The renal vasoconstrictor responses were markedly attenuated by nitrendipine and 5‐methylurapidil in the diabetic rats (all P <0.05). In the non‐diabetic rats, these responses were markedly attenuated by nitrendipine, 5‐methylurapidil, and BMY 7378 (all P <0.05). In both experimental groups, chloroethylclonidine markedly accentuated the renal vasoconstrictions caused by all the adrenergic stimuli (all P <0.05). Conclusion: These observations indicate that α 1A ‐adrenoceptor subtypes play a major role in mediating adrenergically‐induced renal vasoconstriction in the diabetic 2K1C Goldblatt hypertensive rats. In the non‐diabetic 2K1C Goldblatt hypertensive rats, contributions of α 1A and α 1D ‐adrenoceptor subtypes were proposed. Apart from post‐synaptic α 1 ‐adrenoceptors, both in the diabetic and non‐diabetic 2K1C Goldblatt hypertensive rats, the potential involvement of presynaptic α 1 ‐adrenoceptors is also suggested.