Open AccessOrganic anion transporting polypeptide‐1B1 haplotypes in Chinese patients 1
Author(s) -
XU Linyong,
HE Yijing,
ZHANG Wei,
Deng Sheng,
LI Qing,
ZHANG Weixia,
LIU Zhaoqian,
WANG Dan,
HUANG Yuanfei,
ZHOU Honghao,
SUN Zhenqiu
Publication year - 2007
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2007.00643.x
Subject(s) - slco1b1 , haplotype , polymorphism (computer science) , allele , genetics , organic anion transporting polypeptide , gene , allele frequency , population , primer (cosmetics) , biology , genotype , organic anion transporter 1 , microbiology and biotechnology , medicine , single nucleotide polymorphism , chemistry , transporter , environmental health , organic chemistry
Aim: To detect 388G > A and 521T > C variant alleles in the organic anion transporting polypeptide‐1B1 (OATP1B1, encoding gene SLCO1B1) gene. Methods: One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR‐restriction fragment length polymorphism was used to identify the 388G > A polymorphism and a 1‐step tetra‐primer method was developed for the determination of 521T > C mutation. Results: The frequencies of the 388G > A and 521T > C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1 *1b and * 15 haplotypes were 59.9% and 14.0%, respectively. Conclusion: The SLCO1B1 * 1 b and SLCO1B1 * 15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.