Open AccessUpregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus 3
Author(s) -
WANG Cheng,
YOU Zili,
XIA Qing,
XIONG Tao,
XIA Yang,
YAO Dezhong
Publication year - 2007
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2007.00497.x
Subject(s) - downregulation and upregulation , hippocampus , messenger rna , gene expression , microbiology and biotechnology , expression (computer science) , neuroscience , chemistry , biology , gene , computer science , genetics , programming language
Aim: To investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus. Methods: The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially‐expressed genes modulated by JuA in the mouse hippocampus. Results: JuA significantly decreased the total activity intensity ( P < 0.01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity‐regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein 1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus. Conclusion: JuA had an inhibitory effect on the spontaneous activity of the mice, and JuA regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus.