Open AccessThrombolytic efficacy of native recombinant staphylokinase on femoral artery thrombus of rabbits
Author(s) -
LI Chunjian,
HUANG Jun,
YANG Zhijian,
CAO Kejiang
Publication year - 2007
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2006.00455.x
Subject(s) - staphylokinase , medicine , femoral artery , streptokinase , thrombus , thrombosis , urokinase , femoral vein , bolus (digestion) , artery , surgery , anesthesia , recombinant dna , myocardial infarction , biochemistry , chemistry , gene
Aim: To investigate the thrombolytic efficacy, ideal dosage and administration of native recombinant staphylokinase (r‐SAK). Methods: Forty New Zealand rabbits were randomly assigned into the control, r‐SAK low‐dose, medial‐dose, high‐dose, single bolus, allied therapy, recombinant streptokinase (r‐SK) and urokinase (UK) groups. The right femoral artery thrombosis models were made by balloon injury, and 120 min after the injury, the thrombolytic agents were infused through the rabbits’ parallel‐ear vein. Results: (1) 2 h after balloon injury, the pulse pressures of the right femoral arteries reduced to 0 or less than 10% of that of left femoral arteries in all groups; (2) after thrombolytic therapy, the pulse pressures in some of the femoral arteries markedly enhanced to more than 50% of that of left femoral arteries; (3) the reopening rates in the r‐SAK medial and high‐dose groups were significantly higher than that of the control. The reopening rate of the same dose native r‐SAK was significant higher than that of UK and r‐SK; (4) the patency score of the right femoral arteries tended to be better in the r‐SAK medial and high‐dose groups than that of the low‐dose group, and the time to reopening in the allied therapy group tended to be shorter. Conclusion: (1) r‐SAK has a definite thrombolytic effect on the femoral artery thrombus of rabbits; (2) single bolus is an effective manner of r‐SAK therapy, and r‐SAK allied therapy with heparin may shorten the time to recanalization; (3) the efficacy of the same dose native r‐SAK was superior to that of r‐SK and UK.