Open AccessArterial baroreflex function does not influence telomere length in kidney of rats 1
Author(s) -
ZHANG Xiaofei,
YANG Ruifang,
WANG Jin,
ZHAO Lei,
LI Ling,
SHEN Fuming,
SU Dingfeng
Publication year - 2006
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2006.00422.x
Subject(s) - baroreflex , blood pressure , medicine , endocrinology , kidney , mean arterial pressure , heart rate
Aim: To investigate the relationship between arterial baroreflex (ABR) function and telomere length in kidney of rats. Methods: Stroke‐prone spontaneously hypertensive rats (SHR‐SP) and sinoaortic denervated rats (SAD) were used as models with depressed arterial baroreflex. In the first experiments, SHR‐SP rats were examined at the age of 24 weeks for both sexes and 40 weeks for female rats. In the second experiments, SAD rats were studied 4 and 35 weeks after SAD operation. Blood pressure was continuously recorded for 4 h in a conscious state. After the determination of baroreflex sensitivity (BRS), the terminal restriction fragment (TRF) of rat kidney was analyzed using Southern blot. Results: The TRF length was found shorter in: a) male SHR‐SP compared with age‐matched female SHR‐SP; b) female SHR‐SP 40 weeks of age compared with 24 weeks of age; c) in rats 35 weeks after operation compared with rats 4 weeks post operation in both sham‐operated and SAD rats. Conclusion: In SHR‐SP, the TRF length did not correlate with BRS. In addition, SAD did not affect TRF length at either 4 or 35 weeks post‐surgery. It may be concluded that baroreflex function does not influence the terminal restriction fragment (TRF) length in rats.