Open AccessStore‐operated calcium channels and pro‐inflammatory signals
Author(s) -
CHANG Weichiao
Publication year - 2006
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2006.00395.x
Subject(s) - gating , microbiology and biotechnology , voltage dependent calcium channel , calcium signaling , intracellular , chemistry , calcium , t type calcium channel , calcium in biology , biophysics , biology , organic chemistry
In non‐excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and epithelia, the major pathway for calcium (Ca 2+ ) entry is through store‐operated Ca 2+ channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca 2+ stores, however, neither the gating mechanism nor the downstream targets of these channels has been clear established. Here, I review some of the proposed gating mechanisms of store‐operated Ca 2+ channels and the functional implications in regulating pro‐inflammatory signals.