Open AccessHepatotoxicity of anti‐inflammatory and analgesic drugs: ultrastructural aspects 1
Author(s) -
MANOV Irena,
MOTANIS Helen,
FRUMIN Idan,
IANCU Theodore C.
Publication year - 2006
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2006.00278.x
Subject(s) - acetaminophen , drug , analgesic , pharmacology , medicine , verapamil , acetylcysteine , disease , anti inflammatory , antioxidant , chemistry , pathology , biochemistry , calcium
With the increasing incidence of drug‐induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life‐endangering reactions. Analgesics and anti‐inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug‐induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N‐acetylcysteine or the P‐glycoprotein inhibitor verapamil.