Open AccessHistamine ameliorates spatial memory deficits induced by MK‐801 infusion into ventral hippocampus as evaluated by radial maze task in rats 1
Author(s) -
XU Lisha,
YANG Lixia,
HU Weiwei,
YU Xiao,
MA Li,
LIU Luying,
WEI Erqing,
CHEN Zhong
Publication year - 2005
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2005.00229.x
Subject(s) - hippocampus , histamine , nmda receptor , antagonist , neuroscience , anesthesia , chemistry , psychology , medicine , pharmacology , receptor
Aim: To investigate the role of histamine in memory deficits induced by MK‐801 infusion into the ventral hippocampus in rats. Methods: An 8‐arm radial maze (4 arms baited) was used to assess spatial memory. Results: Bilateral ventral intrahippocampal (ih) infusion of MK‐801 (0.3 μg/site), an N‐methyl‐D‐aspartate (NMDA) antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine (25 or 50 ng/site) or intraperitoneal (ip) injection of histidine (25, 50 or 100 mg/kg) markedly ameliorated the spatial memory deficits induced by MK‐801. Both the histamine H1 antagonist pyrilamine (0.5 or 1.0 μg/site, ih) and the H 2 antagonist cimetidine (2.5 μg/site, ih) abolished the ameliorating effect of histidine (100 mg/kg, ip) on reference memory deficits, but not that on working memory deficits induced by MK‐801. Conclusion: The results indicate that histamine in the ventral hippocampus can ameliorate MK‐801‐induced spatial memory deficits, and that histamine's effect on reference memory is mediated by postsynaptic histamine H 1 and H 2 receptors.