Open AccessAntihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng
Author(s) -
XIE Jingtian,
WANG Chongzhi,
WANG Anbao,
WU Jian,
BASILA Daniel,
YUAN Chunsu
Publication year - 2005
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2005.00156.x
Subject(s) - ginseng , intraperitoneal injection , ginsenoside , diabetes mellitus , medicine , araliaceae , oral administration , body weight , glucose tolerance test , endocrinology , pharmacology , insulin resistance , alternative medicine , pathology
Aim: The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice. Methods: Animals received daily intraperitoneal injections of TGCG (100 and 200 mg/kg) or oral administration (150 and 300 mg/kg) for 12 d. Fasting blood glucose levels and body weight were measured after fasting the animals for 4 h. Peripheral glucose use was also measured using an intraperitoneal glucose tolerance test. Results: In the injection group, a high dose of TGCG (200 mg/kg) significantly lowered the fasting blood glucose levels in ob/ob mice on d 12 (153 ± 16 mg/dL vs 203±9.8 mg/dL, P <0.01, compared to vehicle‐treated group). In the oral group, blood glucose decreased notably with a dose of TGCG (300 mg/kg) on d 12 (169.1±12.6 mg/dL vs211.6±13.8 mg/dL, P <0.05, compared to the vehicle‐treated group). Glucose tolerance was also improved markedly in ob/ob mice. Furthermore, a significant reduction in bodyweight ( P <0.05) was observed after 12 d of TGCG (300 mg/kg) treatment in mice from the oral group. Conclusion: The results indicated that in a diabetic ob/ob mouse model TGCG was endowed with significant anti‐hyperglycemic and anti‐obesity properties. Therefore, the total ginsenosides extracted from Chinese ginseng leaves and the stem may have some potential for treating diabetes.