Open AccessInteraction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women
Author(s) -
XU Hong,
LONG Jirong,
LI Miaoxin,
DENG Hongwen
Publication year - 2005
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2005.00122.x
Subject(s) - menarche , endocrinology , estrogen receptor alpha , medicine , alpha (finance) , estrogen , receptor , gene , estrogen receptor , vitamin d and neurology , biology , genetics , breast cancer , cancer , construct validity , nursing , patient satisfaction
Aim: To evaluate whether estrogen receptor α(ER‐α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women. Methods: A total of 390 pre‐menopausal Chinese women were genotyped at the ER‐α Pvu II, X ba I, and VDR Apa I loci using polymerase chain reaction (PCR)‐restriction fragment length polymorphism (RFLP). Results: Neither the ER‐αgene nor the VDR gene individually had significant effects on the age at menarche in our subjects ( P > 0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR Apa I locus, subjects with haplotype PX at the ER‐αgene had, on average, 6 months later onset of menarche than the non‐carriers ( P =0.01). Conclusion: We found that neither the ER‐αgene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women.