Open AccessTelomere and telomerase as targets for anti‐cancer and regeneration therapies 1
Author(s) -
HSU Yihsin,
LIN Jingjer
Publication year - 2005
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2005.00098.x
Subject(s) - telomerase , telomere , ribonucleoprotein , biology , somatic cell , telomerase reverse transcriptase , cancer research , regeneration (biology) , cancer , telomerase rna component , germline , gene , microbiology and biotechnology , genetics , rna
Abstract Telomerase is a ribonucleoprotein that directs the synthesis of telomeric sequence. It is detected in majority of malignant tumors, but not in most normal somatic cells. Because telomerase plays a critical role in cell immortality and tumor formation, it has been one of the targets for anti‐cancer and regeneration drug development. In this review, we will discuss therapeutic approaches based mainly on small molecules that have been developed to inhibit telomerase activity, modulate telomerase expression, and telomerase directed gene therapy.