Open AccessDistribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors 1
Author(s) -
HU Hua,
CHEN Gao,
ZHANG Jianmin,
ZHANG Weiping,
ZHANG Lei,
GE Qiufu,
YAO Hongtian,
DING Wei,
CHEN Zhong,
WEI Erqing
Publication year - 2005
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2005.00092.x
Subject(s) - traumatic brain injury , receptor , leukotriene , medicine , distribution (mathematics) , poison control , pharmacology , human brain , leukotriene c4 , neuroscience , immunology , biology , medical emergency , psychiatry , mathematical analysis , mathematics , asthma
Aim: To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT 2 ), one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors. Methods: Brain specimens were obtained from patients who underwent brain surgery. CysLT 2 in brain tissues was examined using immunohistochemical analysis. Results: CysLT 2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT 2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT 2 was detected in neuron‐ and glial‐appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT 2 expression was recorded in their endothelial cells. Conclusion: CysLT 2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells.