Open AccessRecombinant bispecific antibodies for cancer therapy
Author(s) -
KONTERMANN Roland E
Publication year - 2005
Publication title -
acta pharmacologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.514
H-Index - 90
eISSN - 1745-7254
pISSN - 1671-4083
DOI - 10.1111/j.1745-7254.2005.00008.x
Subject(s) - bispecific antibody , recombinant dna , antibody , effector , immunology , medicine , cancer , computational biology , virology , monoclonal antibody , biology , biochemistry , gene
Bispecific antibodies can serve as mediators to retarget effector mechanisms to disease‐associated sites. Studies over the past two decades have revealed the potentials but also the limitations of conventional bispecific antibodies. The development of recombinant antibody formats has opened up the possibility of generating bispecific molecules with improved properties. This review summarizes recent developments in the field of recombinant bispecific antibodies and discusses further requirements for clinical development.