Open AccessEarlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control
Author(s) -
Bailey C. J.,
Prato S. Del,
Eddy D.,
Zinman B.
Publication year - 2005
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/j.1742-1241.2005.00675.x
Subject(s) - medicine , guideline , type 2 diabetes , intervention (counseling) , intensive care medicine , diabetes mellitus , disease , clinical trial , type 1 diabetes , randomized controlled trial , pediatrics , surgery , endocrinology , pathology , nursing
Summary In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression.