Open AccessA Case of Trisomy 28 in Cattle Revealed by both Banding and FISH‐Mapping Techniques
Author(s) -
Iannuzzi Leopoldo,
Meo Giulia Pia,
Leifsson Pàll S.,
Eggen André,
Christensen Knut
Publication year - 2001
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.2001.00147.x
Subject(s) - biology , trisomy , supernumerary , fish <actinopterygii> , chromosome , genetics , karyotype , g banding , anatomy , gene , fishery
A case of presumed trisomy 22 in cattle, as earlier reported, was investigated by using both chromosome banding and FISH‐mapping techniques. A one year old Hereford female calf showed slow growth, brachygnathia superior, hyper‐salivation, strabisbusmus convergence, macroclitoris and supernumerary nipples. At necropsy, a duplication of the uterine cervix and an extra aortic cusp were also observed. The R‐banding technique revealed that BTA28 (not BTA22, as erroneously earlier reported) was involved in the trisomy. This was confirmed by FISH‐mapping with chromosome‐specific markers. Phenotypic characteristics achieved in cattle carrier and those earlier reported in humans carrying partial trisomy 10 were discussed.