Open AccessP II signal transduction proteins: nitrogen regulation and beyond
Author(s) -
Huergo Luciano F.,
Chandra Govind,
Merrick Mike
Publication year - 2013
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1111/j.1574-6976.2012.00351.x
Subject(s) - archaea , biology , effector , signal transduction , bacteria , membrane protein , enzyme , biochemistry , transcription factor , microbiology and biotechnology , genetics , gene , membrane
The P II proteins are one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably, P II proteins control the activities of a diverse range of enzymes, transcription factors and membrane transport proteins, and in recent years the extent of these interactions has been recognized to be much greater than heretofore described. Major advances have been made in structural studies of P II proteins, including the solution of the first structures of P II proteins complexed with their targets. We have also begun to gain insights into how the key effector molecules, 2‐oxoglutarate and ATP / ADP , influence the activities of P II proteins. In this review, we have set out to summarize our current understanding of P II biology and to consider where future studies of these extraordinarily adaptable proteins might lead us.