Open AccessNovel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy
Author(s) -
Van De Veerdonk Frank L.,
Netea Mihai G.,
Joosten Leo A.,
Van Der Meer Jos W.M.,
Kullberg Bart Jan
Publication year - 2010
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1111/j.1574-6976.2010.00232.x
Subject(s) - candida infections , immunotherapy , adjuvant , candida albicans , mucocutaneous zone , immunology , biology , disease , intensive care medicine , medicine , immune system , microbiology and biotechnology
Infections caused by Candida spp. continue to be a substantial cause of disease burden, especially in immunocompromised patients. New approaches are needed to improve the outcome of patients suffering from Candida infections, because it seems unlikely that the established standard treatment will drastically lower the morbidity of mucocutaneous Candida infections and the high mortality associated with invasive candidiasis. New insights into the mechanisms of the anti‐ Candida host response have contributed to the design of novel immunotherapeutic approaches that have been proposed as adjuvant therapy in Candida infections. This review presents an overview of novel strategies in the prevention and treatment of Candida infections, with a special focus on adjuvant immunotherapy.