Open AccessHow Saccharomyces cerevisiae copes with toxic metals and metalloids
Author(s) -
Wysocki Robert,
Tamás Markus J.
Publication year - 2010
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1111/j.1574-6976.2010.00217.x
Subject(s) - metalloid , saccharomyces cerevisiae , arsenic , biology , mercury (programming language) , detoxification (alternative medicine) , antimony , cadmium , budding yeast , toxicity , yeast , metal toxicity , heavy metals , environmental chemistry , metal , biochemistry , chemistry , medicine , inorganic chemistry , alternative medicine , organic chemistry , pathology , computer science , programming language
Toxic metals and metalloids are widespread in nature and can locally reach fairly high concentrations. To ensure cellular protection and survival in such environments, all organisms possess systems to evade toxicity and acquire tolerance. This review provides an overview of the molecular mechanisms that contribute to metal toxicity, detoxification and tolerance acquisition in budding yeast Saccharomyces cerevisiae . We mainly focus on the metals/metalloids arsenic, cadmium, antimony, mercury, chromium and selenium, and emphasize recent findings on sensing and signalling mechanisms and on the regulation of tolerance and detoxification systems that safeguard cellular and genetic integrity.