Open AccessFunctional role of bacterial multidrug efflux pumps in microbial natural ecosystems
Author(s) -
Martinez Jose Luis,
Sánchez María Blanca,
MartínezSolano Laura,
Hernandez Alvaro,
Garmendia Leonor,
Fajardo Alicia,
AlvarezOrtega Carolina
Publication year - 2009
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1111/j.1574-6976.2008.00157.x
Subject(s) - efflux , biology , virulence , bacteria , microbiology and biotechnology , gene , intracellular , antibiotics , multiple drug resistance , bacterial genetics , antibiotic resistance , horizontal gene transfer , genetics , escherichia coli , genome
Multidrug efflux pumps have emerged as relevant elements in the intrinsic and acquired antibiotic resistance of bacterial pathogens. In contrast with other antibiotic resistance genes that have been obtained by virulent bacteria through horizontal gene transfer, genes coding for multidrug efflux pumps are present in the chromosomes of all living organisms. In addition, these genes are highly conserved (all members of the same species contain the same efflux pumps) and their expression is tightly regulated. Together, these characteristics suggest that the main function of these systems is not resisting the antibiotics used in therapy and that they should have other roles relevant to the behavior of bacteria in their natural ecosystems. Among the potential roles, it has been demonstrated that efflux pumps are important for processes of detoxification of intracellular metabolites, bacterial virulence in both animal and plant hosts, cell homeostasis and intercellular signal trafficking.