Open AccessRegulation of whole bacterial pathogen transcription within infected hosts
Author(s) -
La MyVan,
Raoult Didier,
Renesto Patricia
Publication year - 2008
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1111/j.1574-6976.2008.00103.x
Subject(s) - biology , in silico , dna microarray , transcriptome , pathogen , bacterial transcription , microbiology and biotechnology , computational biology , bacteria , microarray , transcription (linguistics) , gene , host (biology) , bacterial genetics , gene expression , genetics , escherichia coli , promoter , linguistics , philosophy
DNA microarrays are a powerful and promising approach to gain a detailed understanding of the bacterial response and the molecular cross‐talk that can occur as a consequence of host–pathogen interactions. However, published studies mainly describe the host response to infection. Analysis of bacterial gene regulation in the course of infection has confronted many challenges. This review summarizes the different strategies used over the last few years to investigate, at the genomic scale, and using microarrays, the alterations in the bacterial transcriptome in response to interactions with host cells. Thirty‐seven studies involving 19 different bacterial pathogens were compiled and analyzed. Our in silico comparison of the transcription profiles of bacteria grown in broth or in contact with eukaryotic cells revealed some features commonly observed when bacteria interact with host cells, including stringent response and cell surface remodeling.