Open AccessTranslation initiation and the fate of bacterial mRNAs
Author(s) -
Kaberdin Vladimir R.,
Bläsi Udo
Publication year - 2006
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1111/j.1574-6976.2006.00043.x
Subject(s) - biology , translation (biology) , messenger rna , untranslated region , ribosome , ribosomal binding site , rna , rna binding protein , genetics , three prime untranslated region , microbiology and biotechnology , translational regulation , protein biosynthesis , computational biology , gene
Studies in pro‐ and eukaryotes have revealed that translation can determine the stability of a given messenger RNA. In bacteria, intrinsic mRNA signals can confer efficient ribosome binding, whereas translational feedback inhibition or environmental cues can interfere with this process. Such regulatory mechanisms are often controlled by RNA‐binding proteins, small noncoding RNAs and structural rearrangements within the 5′ untranslated region. Here, we review molecular events occurring in the 5′ untranslated region of primarily Escherichia coli mRNAs with regard to their effects on mRNA stability.