Open AccessOsmoregulation and glycerol metabolism in the yeast Saccharomyces cerevisiae
Author(s) -
Nevoigt Elke,
Stahl Ulf
Publication year - 1997
Publication title -
fems microbiology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.91
H-Index - 212
eISSN - 1574-6976
pISSN - 0168-6445
DOI - 10.1111/j.1574-6976.1997.tb00352.x
Subject(s) - saccharomyces cerevisiae , glycerol , extracellular , metabolism , intracellular , biology , biochemistry , yeast , osmoregulation , osmotic concentration , ecology , salinity
Glycerol is the main compatible solute in Saccharomyces cerevisiae . It is accumulated intracellularly when cells are exposed to decreased extracellular water activity. In general, increased intracellular accumulation of a solute may be caused by enhanced production, restricted dissimilation, increased retention by the plasma membrane and increased uptake from the medium. In this review, we evaluate current knowledge concerning mechanisms leading to the accumulation of glycerol in osmotically stressed cells of S. cerevisiae at the molecular and metabolic levels. An overview of glycerol metabolism in S. cerevisiae is provided.