Open AccessInvestigation into the role of five S almonella enterica serovar E nteritidis genomic islands in colonization of the chicken reproductive tract and other organs following oral challenge
Author(s) -
Coward Chris,
Sait Leanne,
Williams Lisa,
Humphrey Tom J.,
Cogan Tristan,
Maskell Duncan J.
Publication year - 2012
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2012.02652.x
Subject(s) - salmonella enterica , colonization , biology , gastrointestinal tract , serotype , reproductive tract , spleen , microbiology and biotechnology , salmonella enteritidis , salmonella , genome , female reproductive tract , virology , bacteria , gene , genetics , immunology , endocrinology , biochemistry , sperm
S almonella enterica serovar E nteritidis is a major cause of human gastrointestinal tract disease, infection being due in large part to the consumption of contaminated eggs. Recent genome sequencing of S . enterica serovars has identified genomic islands, the presence of which differs between serovars. Using defined mutants, we have investigated the contribution that five such loci play in the colonization of the avian reproductive tract, other organs and avian macrophages. All loci appear to play a small role in infection of liver and spleen, but not in colonization of the reproductive tract or macrophages.