Open AccessThe Nla6S protein of M yxococcus xanthus is the prototype for a new family of bacterial histidine kinases
Author(s) -
Sarwar Zaara,
Garza Anthony G.
Publication year - 2012
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2012.02639.x
Subject(s) - myxococcus xanthus , biology , myxobacteria , histidine kinase , kinase , gene , microbiology and biotechnology , protein family , signal transduction , histidine , 14 3 3 protein , genetics , bacteria , amino acid , phosphorylation , mutant
M yxococcus xanthus has a large number of histidine kinase ( HK ) signal transduction proteins and many of these HK s are important for fruiting body development. Nla6S is an uncharacterized HK that lacks many of the conserved sequence motifs of typical HK proteins. In this study, we report that expression of the nla6S gene increases about sixfold during fruiting body development, that the Nla6S protein has the in vitro properties of HK s and that Nla6S is the prototype for a new family of HK s. To date, these N la6‐like HK s are found only in fruiting members of the C ystobacterineae suborder of the myxobacteria.